Glossary · Treatments

Gabapentin

Also called: Neurontin.

Definition: Gabapentin is an anticonvulsant used off-label for hot flashes, particularly nighttime hot flashes that disrupt sleep. Bedtime dosing of 300–900 mg can reduce hot flash frequency and improve sleep, making it a useful non-hormonal option for women whose primary complaint is night sweats.

Detailed definition

Gabapentin, originally developed as an anticonvulsant, is structurally similar to GABA but acts primarily on voltage-gated calcium channels rather than GABA receptors. Multiple RCTs show modest reductions in hot flash frequency (roughly 25–45%) at doses of 300–900 mg/day, with the strongest evidence for nighttime dosing reducing night sweats and improving sleep. Side effects include daytime sedation, dizziness, and weight gain. Pregabalin (Lyrica) has similar effects with a smaller evidence base.

Why it matters in menopause

For women whose dominant menopause complaint is nighttime hot flashes that destroy sleep — and who cannot or do not want to use estrogen — bedtime gabapentin is a useful option. Many menopause practices use it as a sleep-VMS combined intervention.

Sources

External references: Wikipedia.

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