Estrogen Vaginal Cream

Vaginal Estrogen

Estrogen Vaginal Cream

4.8 (180 reviews)
$49 /first month $99

Save $50 — 50% off your first order. Then $99/month.

Low-dose estradiol vaginal cream for targeted relief of vaginal dryness, irritation, painful intercourse, and urinary urgency — with minimal systemic absorption.

Get Started — Prescription Required

A licensed physician will review your information before dispensing.

Free shipping on every order
30-day money-back guarantee
Board-certified physician review included
Discreet packaging, HIPAA compliant

About This Treatment

Estradiol vaginal cream delivers low-dose estrogen directly to vaginal tissues, restoring moisture, elasticity, and pH balance. Because it is applied locally, systemic absorption is minimal — making it an option even for some women who cannot take systemic estrogen. It is highly effective for genitourinary syndrome of menopause (GSM), which affects up to 50% of postmenopausal women and includes vaginal dryness, burning, irritation, painful intercourse, and urinary urgency. Results are typically noticeable within 2–4 weeks of regular use.

Active Ingredients

Estradiol 0.01% Cream

Ultra-low dose estradiol in a soothing cream base for targeted vaginal tissue restoration.

Cream Base

Emollient, non-irritating base with aloe vera and vitamin E. Fragrance-free and dye-free.

Symptoms Addressed

  • Vaginal dryness & atrophy
  • Painful intercourse (dyspareunia)
  • Vaginal burning & irritation
  • Urinary urgency & frequency
  • Recurrent UTIs
  • Low libido related to discomfort

"Prescription required. A licensed physician will review your medical information before this treatment is dispensed. For US residents only."

What patients are saying

"I didn't realize how much vaginal dryness was affecting my quality of life until it was gone. This cream fixed it completely within a month."

Rose T.
Rose T.Boca Raton, FL
Verified Patient

"My gynecologist suggested I try this. The ClearedRx process was so much easier than going through my insurance. And it's a fraction of the cost."

Marcia B.
Marcia B.Houston, TX
Verified Patient

"I was embarrassed to talk about this with my regular doctor. ClearedRx made it easy, private, and affordable."

Connie L.
Connie L.Phoenix, AZ
Verified Patient

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