Estrogen + Progesterone Vaginal Cream

HRT Cream  ·  Most Popular

Estrogen + Progesterone Vaginal Cream

4.8 (180 reviews)
$89 /first month $189

Save $100 — 50% off your first order. Then $189/month.

The same full-spectrum 3-in-1 formula as our Body Cream — estradiol, estriol, and progesterone — with the added benefit of targeted local relief for vaginal dryness, irritation, and urinary health.

Get Started — Prescription Required

A licensed physician will review your information before dispensing.

Free shipping on every order
30-day money-back guarantee
Board-certified physician review included
Discreet packaging, HIPAA compliant

About This Treatment

The Estrogen + Progesterone Vaginal Cream combines systemic menopause relief with targeted local therapy. The estradiol and estriol in the formula address hot flashes, night sweats, mood, and sleep at a systemic level, while also restoring vaginal tissue health, elasticity, and moisture. Progesterone provides uterine protection and supports deeper, more restorative sleep. This cream is ideal for women experiencing both systemic menopause symptoms and genitourinary symptoms of menopause (GSM) such as vaginal dryness, painful intercourse, or urinary urgency.

Active Ingredients

Estradiol

The primary estrogen for systemic menopause symptom relief — hot flashes, bone density, cognitive clarity, and skin health.

Estriol

A gentler estrogen that specifically supports vaginal tissue health, moisture, and urinary tract function.

Progesterone

Balances estrogen, protects the uterine lining, and supports deep restorative sleep via the GABA pathway.

Symptoms Addressed

  • Hot flashes & night sweats
  • Vaginal dryness & irritation
  • Painful intercourse
  • Urinary urgency & frequency
  • Sleep disruption
  • Mood swings & anxiety
  • Brain fog
  • Low libido

"Prescription required. A licensed physician will review your medical information before this treatment is dispensed. For US residents only."

What patients are saying

"I had no idea vaginal dryness was a menopause symptom until my doctor explained it. This cream fixed it within 3 weeks. Life-changing."

Donna R.
Donna R.Phoenix, AZ
Verified Patient

"The intimacy issues were really affecting my relationship. ClearedRx gave me back my confidence and my comfort. I can't recommend it enough."

Karen L.
Karen L.Nashville, TN
Verified Patient

"I love that I only need one product. The cream addresses everything — the hot flashes, the dryness, the sleep. It's all in one."

Pam S.
Pam S.Portland, OR
Verified Patient

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