Detailed definition
Clonidine is an alpha-2 adrenergic agonist that reduces sympathetic outflow. For vasomotor symptoms, evidence shows a modest reduction in hot flash frequency (roughly 15–30%), notably less than HRT, fezolinetant, or paroxetine. It is available as oral tablets or transdermal patches. Side effects include hypotension, dizziness, dry mouth, sedation, and rebound hypertension on discontinuation. It is rarely first-line for VMS in modern practice but is occasionally useful for women with concurrent hypertension or who cannot use other options.
Why it matters in menopause
Clonidine has a small remaining role for women who are not candidates for estrogen, SSRIs/SNRIs, gabapentin, or fezolinetant. It is rarely the first choice but can fit specific clinical situations.
Related terms
Sources
External references: Wikipedia.