What this trial studies
The purpose of this study is to evaluate if folic acid improves endothelial sensitivity to shear stress in post-menopausal women.
Conditions in scope
- Healthy Aging
- Aging
- Menopause
Interventions
- Folic Acid (Dietary Supplement) — Folic acid (5 mg)
- Placebo (Other) — Placebo capsule
Who can join
All sexes · Ages 50 Years to 80 Years · Accepts healthy volunteers.
Inclusion criteria
- ≥ 1-year amenorrhea
- Body mass index ≤ 30 kg/m2
- Resting blood pressure \< 140 / \< 90 mmHg
- Non-smoker (≥ 1-year)
Exclusion criteria
- Diagnosis of cardiac, vascular, respiratory, neurological or metabolic disease and/or a prescription of medications for the treatment of such diseases.
- For female participants, hormonal replacement therapy within 1 year of enrolment in the study.
- For female participants, having undergone an ovariectomy.
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Montreal | Quebec | Cardiovascular Prevention and Rehabilitation Centre of the Montreal Heart Institute | Unknown |
Status & timeline
- Overall status: Completed
- Study type: Interventional
- Phase: N/A
- Start date: 2019-09-09
- Primary completion: 2024-04-03
- Last update posted: 2024-12-12
- First posted: 2019-07-11
Sponsor & contact
Lead sponsor: Montreal Heart Institute (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Endothelial sensitivity to shear rate (Measured 2 hours after placebo or folic acid consumption)
Change in brachial artery diameter for given levels of shear rate during rhythmic handgrip exercise
Related ClearedRx care
If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.
Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT04016090 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.