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Menopause Clinical Trials

Menopause & HRT clinical trials, indexed in plain English.

388 ClinicalTrials.gov studies covering menopause, perimenopause, hot flashes, GSM, postmenopausal osteoporosis, and HRT-related interventions. Each page paraphrases the official record into plain English and links straight to ClinicalTrials.gov for the source of truth. Refreshed May 8, 2026.

Browse by topic

47 trials

Hot flashes & night sweats

Trials studying treatments for hot flashes and other vasomotor symptoms.

Browse 44 trials

Vaginal dryness & GSM

Trials targeting genitourinary syndrome of menopause — vaginal dryness, painful sex, urinary symptoms.

Browse 20 trials

Postmenopausal osteoporosis

Trials on bone density, fracture risk, and osteoporosis treatment in postmenopausal women.

Browse 24 trials

Estrogen & progesterone HRT

Trials of estrogen, estradiol, progesterone, and combination HRT formulations.

Browse 23 trials

Non-hormonal options

Trials of fezolinetant, paroxetine, gabapentin, CBT, and other non-hormonal approaches.

Browse 136 trials

Currently recruiting

Trials open for new participants right now.

Browse

Hot flashes & night sweats (47 of 47)

Trials studying treatments for hot flashes and other vasomotor symptoms.

Vaginal dryness & GSM (44 of 44)

Trials targeting genitourinary syndrome of menopause — vaginal dryness, painful sex, urinary symptoms.

Postmenopausal osteoporosis (20 of 20)

Trials on bone density, fracture risk, and osteoporosis treatment in postmenopausal women.

Estrogen & progesterone HRT (24 of 24)

Trials of estrogen, estradiol, progesterone, and combination HRT formulations.

Non-hormonal options (23 of 23)

Trials of fezolinetant, paroxetine, gabapentin, CBT, and other non-hormonal approaches.

Currently recruiting (50 of 136)

Trials open for new participants right now.

All trials (388)

Sorted by most-recently-updated on ClinicalTrials.gov. NCT ID first, then trial title.

Frequently asked

What is a menopause clinical trial?

A menopause clinical trial is a research study that tests how a treatment, drug, device, or behavior change affects menopause symptoms or related conditions like vasomotor symptoms, vaginal dryness (GSM), or postmenopausal osteoporosis. Trials are listed on ClinicalTrials.gov, a public registry maintained by the US National Library of Medicine.

Where does ClearedRx get this trial data?

Every trial page on this site is built from the public ClinicalTrials.gov v2 API. We index trials whose conditions or interventions match the menopause/HRT topic set, paraphrase the brief summary into plain English, and link directly to the official record. Last refreshed May 8, 2026.

Are these trials currently enrolling?

Trials marked "Recruiting" or "Enrolling by invitation" are open for new participants. Trials marked "Active, not recruiting", "Completed", or "Terminated" are not. Status changes often, so always confirm on the official ClinicalTrials.gov record before contacting a study site.

How do I join a menopause trial?

Each trial page links to the official ClinicalTrials.gov record, which lists site locations and contact information. ClearedRx does not enroll patients in trials — we index the public records as a research and education resource.

Is ClearedRx a clinical trial sponsor?

No. ClearedRx is a telehealth brand that prescribes FDA-approved and compounded HRT through a network of board-certified MDs licensed in all 50 US states. We index ClinicalTrials.gov records to help patients understand the evidence base for menopause care — we are not affiliated with the trial sponsors.

Can I get HRT without joining a trial?

Yes. ClearedRx prescribes the same FDA-approved and compounded HRT formulations that have been studied in trials like these for decades. A 3-minute online intake routes your case to a board-certified MD licensed in your state, who reviews within 24 hours and ships your medication in 3-5 business days at a flat $19-$89/month.

Trial data sourced from ClinicalTrials.gov, a public service of the US National Library of Medicine. ClearedRx is not affiliated with any trial or sponsor listed here. Always verify the official record before contacting a site.