Aerobic vs Resistance Exercise in Post-menopausal Women With Type 1 Diabetes

What this trial studies

Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third will be a moderate weight-lifting session (\~30 minutes of exercise, 60 minutes of recovery).The investigators will measure changes in blood glucose during exercise by drawing blood during and after exercise. Post-exercise glucose trends will be examined using continuous glucose monitoring.

Conditions in scope

• Type 1 Diabetes
• Post-menopause

Interventions

• Aerobic Exercise (Other) — Walking at 60% of maximal aerobic capacity on a treadmill
• Resistance Exercise (Other) — Performing one set of 10 repetitions of 10 different weight-lifting exercises
• No exercise (Other) — Participants will rest in a supine position for 30 minutes.

Who can join

Women only · Ages 45 Years to 75 Years

Inclusion criteria

• type 1 diabetes, diagnosed for at least one year
• post-menopause (at least one year since last menstrual period), or have had a hysterectomy and bilateral salpingo oophorectomy
• able to perform aerobic and resistance exercise
• able to visit the lab in Edmonton, Alberta (University of Alberta)

Exclusion criteria

• HbA1c \> 9.9 %
• frequent and unpredictable hypoglycemia
• change in insulin management strategy within the last 2 months
• blood pressure \> 140 / 95
• severe peripheral neuropathy
• history of cardiovascular disease
• musculoskeletal injuries interfering with exercise performance
• use of medications (other than insulin) that affect glucose metabolism

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Recruiting
• Study type: Interventional
• Phase: N/A
• Start date: 2021-11-16
• Primary completion: 2027-03-30
• Last update posted: 2026-03-16
• First posted: 2022-01-12

Sponsor & contact

Lead sponsor: University of Alberta (Other)

Collaborators: Women and Children's Health Research Institute, Canada

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Blood glucose (From 0 minutes to 45 minutes (beginning to the end of exercise/control) and then for 60 minutes after exercise)
  Change in blood glucose

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