Effects of Beef Consumption on Skeletal Muscle Protein Homeostasis and Inflammatory Factors in Pre- and Postmenopausal Females

What this trial studies

This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.

Conditions in scope

• Menopause Related Conditions

Interventions

• meals consisting of primarily animal protein sources (Other) — an omnivorous diet
• meals consisting of plant protein sources (Other) — an herbivorous diet

Who can join

Women only · Ages 35 Years to 65 Years · Accepts healthy volunteers.

Inclusion criteria

• Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months).
• Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months).
• BMI of 20.0 - 34.9 kg/m2.
• COVID-19 negative and/or asymptomatic

Exclusion criteria

• Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month.
• Unable to stop the use of anti-inflammatory drugs for the week prior to and during study.
• Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus).
• Currently pregnant.
• Gave birth or was lactating within previous 12 months.
• Undergone gastric bypass/bariatric surgery.
• Clinically significant weight gain or loss (\>5% change) in the last 12 months.
• Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication).

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Completed
• Study type: Interventional
• Phase: N/A
• Start date: 2023-08-28
• Primary completion: 2025-04-01
• Last update posted: 2025-05-06
• First posted: 2023-02-06

Sponsor & contact

Lead sponsor: University of Arkansas (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Net change in muscle protein synthesis (% per day). (Study meals are eaten for 5 consecutive days.)
  Change in net muscle protein synthesis between groups.

Related ClearedRx care

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