Serum Concentration of Endogenous Estrogens and Sirtuin-1 After Administration of Atorvastatin and Quercetin:

What this trial studies

Chronic coronary syndrome (CCS) is the leading cause of death in women in the most developed regions of Brazil. The primary etiopathogenic mechanism is the process of atherosclerosis. A healthy diet rich in fruits and vegetables is associated with a lower incidence of CCS. The higher consumption of these foods promotes greater availability of phenolic compounds, and the higher intake of these compounds is one of the main hypotheses for vascular health.

Conditions in scope

• Coronary Artery Disease
• Menopause

Interventions

• Quercetin (Dietary Supplement) — Trans-quercetin, 1000 mg daily for 60 days
• Placebo (Dietary Supplement) — Starch, 1000 mg daily for 60 days

Who can join

Women only · Ages 55 Years to 70 Years

Inclusion criteria

• Postmenopausal women;
• Diagnosed coronary artery disease;
• Stable coronary disease;

Exclusion criteria

• hypo or hyperthyroidism,
• rheumatic disease,
• use of alcohol,
• hepatic failure,
• renal failure
• hormone replacement therapy
• use of insulin

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Completed
• Study type: Interventional
• Phase: N/A
• Start date: 2021-10-03
• Primary completion: 2023-12-23
• Last update posted: 2025-12-19
• First posted: 2023-05-26

Sponsor & contact

Lead sponsor: InCor Heart Institute (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Estradiol (60 days)
  serum concentrations
• Estrone (60 days)
  serum concentrations
• Sirtuin-1 (60 days)
  Serum concentrations and gene expression

Related ClearedRx care

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