What this trial studies
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Conditions in scope
- Aging
- Menopause
- Hypoxia
- Vasodilation
Interventions
- Placebo (Drug) — Participants will receive a placebo in pill form.
- Propranolol (Drug) — Participants will receive oral propranolol (1 mg/kg).
- Gemtesa (Drug) — Participants will receive oral gemtesa (75 mg).
Who can join
Women only · Ages 18 Years to 70 Years · Accepts healthy volunteers.
Inclusion criteria
- Female assigned at birth
- Pre, peri- or post-menopausal
- Healthy weight (BMI ≥18 and ≤30 kg/m2)
Exclusion criteria
- Male (assigned at birth)
- Pregnancy, breastfeeding
- Use of hormone replacement therapies
- Hysterectomy
- Body mass index \>30 kg/m2
- Diagnosed sleep apnea
- Current smoking/Nicotine/Drug use
- Nerve/neurologic disease
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Columbia | Missouri | University of Missouri-Columbia | Recruiting |
Status & timeline
- Overall status: Recruiting
- Study type: Interventional
- Phase: EARLY_PHASE1
- Start date: 2024-06-03
- Primary completion: 2026-07
- Last update posted: 2025-09-09
- First posted: 2024-05-16
Sponsor & contact
Lead sponsor: University of Missouri-Columbia (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Forearm blood flow (Change from baseline to 5 minutes.)
Blood flow in the forearm measured with venous occlusion plethysmography.
Related ClearedRx care
If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.
Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT06417177 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.