What this trial studies
The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.
Conditions in scope
- Myocardial Stiffness
Interventions
- Stress Echocardiogram (Diagnostic Test) — Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.
- Cardiovascular Magnetic Imaging (cMRI) (Diagnostic Test) — Non-invasive imaging scan used to examine function and structure of the heart
- Cardiac Magnetic Resonance Elastography (cMRE) (Diagnostic Test) — Non-invasive imaging scan used to measure myocardial stiffness
Who can join
All sexes · Ages 40 Years to 70 Years · Accepts healthy volunteers.
Inclusion criteria
- Longstanding history of competitive endurance athletic performance defined as \>15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.
Exclusion criteria
- A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
- Current or recent pregnancy within 1 year
- Positive pregnancy test (study visit 1)
- Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
- Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Rochester | Minnesota | Mayo Clinic | Unknown |
Status & timeline
- Overall status: Completed
- Study type: Observational
- Phase: N/A
- Start date: 2024-09-14
- Primary completion: 2025-10-06
- Last update posted: 2025-11-06
- First posted: 2024-06-26
Sponsor & contact
Lead sponsor: Mayo Clinic (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Myocardial stiffness (Day 14)
Myocardial stiffness will be measured by magnetic resonance elastography (kPa)
Related ClearedRx care
If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.
Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT06475768 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.