BEETROOT JUICE INTAKE in POSTMENOPAUSAL HYPERTENSIVE WOMEN

What this trial studies

The goal of this clinical trial is to verify the hemodynamic and biomarker responses of beetroot juice intake in postmenopausal women with hypertension. The main questions it aims to answer are: Is beetroot juice dose related to better hemodynamic responses in hypertensive postmenopausal women? Is beetroot juice dose related to better oxidative stress profile responses in hypertensive postmenopausal women? The investigators will conduct a parallel clinical study with 10 days of intervention, in which 48 women will be randomized into 3 groups: 1) Two shots of beetroot juice intake per day (800mg of NO3-); 2) One shot of beetroot juice intake per day (400mg of NO3-); 3) placebo intake (beetroot juice without NO3-).

Conditions in scope

• Hypertension
• Menopause

Interventions

• 1 dose of Beetroot juice intake (Dietary Supplement) — The volunteers will ingest 70 ml of beetroot juice with 400 mg of nitrate every morning for 10 days
• 2 doses of Beetroot juice intake (Dietary Supplement) — This group will ingest 2 shots of 70 ml of beetroot juice with 400mg of nitrate, in each shot, for 10 days.
• Placebo (Dietary Supplement) — In this group, the participants will receive 70ml of low-nitrate beetroot juice to consume in the morning.

Who can join

Women only · Ages 45 Years to 65 Years

Inclusion criteria

• Amenorrhea for at least 12 months
• Controlled hypertension

Exclusion criteria

• Decompensated hypertension in stages 2 and 3
• Having a history of stroke or acute myocardial infarction
• Smoker
• Having a diagnosis of Diabetes Mellitus
• Using hormone therapy.

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Active, not recruiting
• Study type: Interventional
• Phase: N/A
• Start date: 2024-08-07
• Primary completion: 2025-07
• Last update posted: 2024-09-23
• First posted: 2024-09-04

Sponsor & contact

Lead sponsor: Federal University of Uberlandia (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Blood Pressure (11 days)
  Volunteers will undergo blood pressure tests at the beginning, in the middle and after the 10 days of intervention. To assess blood pressure (BP), researchers will use the Dyna Mapa + Cardius® device, programmed with measurements to be taken every 20 min. Together with this device, the volunteers filled out a daily record of activities such as sleep, work, food,…

Related ClearedRx care

If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.