Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

What this trial studies

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Conditions in scope

• Menopause

Interventions

• Propranolol Hydrochloride (Drug) — Examine how IV propranolol impacts sympathetic transduction
• Phentolamine Injection (Drug) — Examine how IV phentolamine impacts sympathetic transduction

Who can join

Women only · Ages 18 Years to 70 Years · Accepts healthy volunteers.

Inclusion criteria

• Assigned female at birth
• years of age
• Body mass index (BMI) \<30 kg/m2

Exclusion criteria

• Assigned male at birth
• Pregnancy, breastfeeding
• Body mass index ≥30 kg/m2
• Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
• Current smoking/nicotine use
• Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
• Nerve/neurologic disease
• Cardiovascular, hepatic, renal, respiratory disease

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Recruiting
• Study type: Interventional
• Phase: EARLY_PHASE1
• Start date: 2025-07-10
• Primary completion: 2026-12
• Last update posted: 2025-09-15
• First posted: 2025-01-22

Sponsor & contact

Lead sponsor: University of Missouri-Columbia (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Sympathetic transduction (1 day (single study visit))
  Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.

Related ClearedRx care

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