What this trial studies
Application of tear ferning test for clinical dry eye diagnosis and menopause
Conditions in scope
- Dry Eye Syndromes
Interventions
- Pre-manepausal women (Other) — Compare tear ferning structure between pre-menopause and post-menopause women.
Who can join
Women only · Ages 20 Years to 65 Years · Accepts healthy volunteers.
Inclusion criteria
- Aged between 20 and 65 years
Exclusion criteria
- No evident ocular diseases such as cornea, cataracts, vitreous degeneration, glaucoma, and retinopathy.
- Belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Taichung | Taiwan | Jen-Ai Hospital | Recruiting |
Status & timeline
- Overall status: Recruiting
- Study type: Interventional
- Phase: N/A
- Start date: 2024-10-01
- Primary completion: 2025-09-01
- Last update posted: 2025-02-27
- First posted: 2025-02-27
Sponsor & contact
Lead sponsor: Chung Shan Medical University (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Schirmer's test (5 minutes)
To assess tear secretion volume - Tear film breakup time (20 seconds)
To assess tear quality - Ocular surface status (3 minutes)
To assess ocular surface health status with lissamine green stain, health or corneal abrasion. - Tear ferning (30 minutes)
crystal structure formed from tear drops on a slide be scored. - Menopause related hormone Enzyme-linked immunosorbent assay (ELISA) (3 hours)
To assess FSH/LH/E2/Progesterone/Mc5AC/Lactoferrin concentration between pre- and post-manopause women.
Related ClearedRx care
If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.
Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT06848829 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.