Hemodynamics After Resistance Training

What this trial studies

Women's blood vessel health gets worse after menopause, or "the change of life". Some women exercise less during menopause. Exercise can improve blood vessel health. The investigators want to know if resistance exercise, like lifting weights, can improve blood vessel health in women who are just starting menopause.

Conditions in scope

• Perimenopause

Interventions

• Resistance Training Intervention (Behavioral) — Participants will complete a brief aerobic warm-up and dynamic stretching prior to each strength training session. Participants will complete 9 exercises for all major muscle groups. Strength testing at the baseline study visit will be used to determine initial load.…

Who can join

Women only · Ages 40 Years to 60 Years

Inclusion criteria

• Are between 40-60 years old
• Have had menstrual irregularities in the last 12 months
• Do not currently complete more than two 30-min sessions of structured exercise per week and do not do any resistance training exercise;
• Are not currently pregnant
• Do not smoke or vape nicotine or marijuana
• Have not had an oophorectomy, hysterectomy, or surgical menopause
• Are not currently taking hormone replacement therapy
• Have not taken hormone replacement therapy in the last 6 months

Exclusion criteria

• See ClinicalTrials.gov for full exclusion criteria.

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Recruiting
• Study type: Interventional
• Phase: N/A
• Start date: 2025-06-06
• Primary completion: 2026-03
• Last update posted: 2025-07-11
• First posted: 2025-06-15

Sponsor & contact

Lead sponsor: University of Michigan (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Vascular function (At baseline and the end of the 16 week study period)
  Arterial stiffness and wave reflection will be measured at baseline and following the 16-week study period using cuff-based waveform acquisition and applanation tonometry.
• Endothelial Function (At baseline and the end of the 16 week study period)
  Endothelial function will be measured at baseline and following the 16-week study period using brachial artery flow-mediated dilation measured with vascular ultrasound.

Related ClearedRx care

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