What this trial studies
The goal of this interventional study is to observe the effects of bone marrow stem cell behavior in skeletal muscle of women between 60 to 75 years old after a single moderate resistance exercise session. Plant sterol Rg1, a compound known to enhance stem cell infiltration following exercise in young men will be tested against a placebo in a double blinded crossover design. The main questions to be answered are: * Does Rg1 supplementation alter serum sex hormone levels in recovery from exercise? * Does Rg1 supplementation influence bone marrow stem cell differentiation in skeletal muscles of older women?
Conditions in scope
- Exercise Training
- Post-menopausal Women
- Bone Marrow Stem Cells
- Skeletal Muscle Recovery
Interventions
- exercise following Rg1 consumption (Dietary Supplement) — The effect of Rg1 on exercised skeletal muscle in older women
- Placebo (Dietary Supplement) — Resistance exercise performed 1 hour following placebo consumption
Who can join
Women only · Ages 60 Years to 70 Years · Accepts healthy volunteers.
Inclusion criteria
- sedentary, able to cease medications and supplements for 48 h before and 24 h after exercise session, medically sound for lower body moderate resistance exercise
Exclusion criteria
- use of insulin, sex hormone and immune-modulating medications, smoking and regular alcohol consumption
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Taipei | Taipei | University of Taipei | Unknown |
Status & timeline
- Overall status: Completed
- Study type: Interventional
- Phase: N/A
- Start date: 2022-03-18
- Primary completion: 2022-12-02
- Last update posted: 2025-07-30
- First posted: 2025-07-30
Sponsor & contact
Lead sponsor: University of Taipei (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Stro-1+ bone marrow stem cell area in skeletal muscle biopsies (from enrolment to the end of study at 8 weeks)
Immunofluorescence staining will be used to semi-quantitatively analyze Stro-1+ BMSC presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session. - Nestin+ neural stem cell area in skeletal muscle biopsies (from enrolment to the end of study at 8 weeks)
Immunofluorescence staining will be used to semi-quantitatively analyze Nestin+ neural stem cell presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session. - CD34+/CD31+ vascular stem cell area in skeletal muscle biopsies (from enrolment to the end of study at 8 weeks)
Immunofluorescence staining will be used to semi-quantitatively analyzeCD34+/CD31+ vascular stem cell presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session. - Serum sex hormone levels 24 h following resistance exercise (from enrolment to the end of study at 8 weeks)
Forearm blood draw and Elisa analysis of serum for estradiol, progesterone, and testosterone of older women before and 24h after a moderate resistance exercise session.
Related ClearedRx care
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Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT07093190 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.