Smart Technology-Based Intervention and Monitoring of Physical and Mental Health in Early Postmenopausal Women

What this trial studies

The aim of this study is to compare the short-term and long-term effects of an 8-week home-based multimodal exercise program, delivered through a smartphone app, on quality of life, muscle function, and physical performance in early postmenopausal women.

Conditions in scope

• Postmenopausal
• Postmenopausal Disorder
• Menopause

Interventions

• Home-based multimodal exercise (Other) — Mobile Applications
• Supervised multimodal exercise program (Other) — In laboratory
• Education (Other) — Menopause education

Who can join

Women only · Ages 40 Years to 65 Years

Inclusion criteria

• to 65-year-old postmenopausal women
• At least 12 months of amenorrhea
• Within 6 years after menopause

Exclusion criteria

• Exercised more than twice a week for at least 30 minutes per session
• Received hormone therapy in the past three months
• Neurological disease (e.g., spinal cord injury, multiple sclerosis, stroke) or cardiovascular diseases
• History of pelvic or prolapse surgery (excluding cesarean section)
• History of malignancy affecting the bladder, urethra, uterus, ovary, cervix, or rectum
• Using medications that could affect heart rate or mood
• Body mass index (BMI) \> 35 kg/m²

Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.

Where it’s happening

Status & timeline

• Overall status: Recruiting
• Study type: Interventional
• Phase: N/A
• Start date: 2025-08-15
• Primary completion: 2028-07-30
• Last update posted: 2026-04-14
• First posted: 2025-08-20

Sponsor & contact

Lead sponsor: YI-JU TSAI (Other)

For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.

Outcome measures

Primary outcomes

• Muscle function measures for lumbopelvic muscle: Abdominal and back muscles (Changes from baseline to 8 weeks when participants finish the intervention.)
  Ultrasonography images of muscle thickness of abdominal and back muscles during rest and during active straight leg raise. Each condition will be tested three times. Muscle thickness at rest and during contraction will be measured using ImageJ, with results expressed in millimeters (mm)
• Muscle function measures for lumbopelvic muscle (Changes from baseline to 8 weeks when participants finish the intervention.)
  Ultrasonography images of bladder displacement for pelvic floor muscles during rest, maximum contraction, and during active straight leg raise. Each condition will be tested three times. Bladder height differences between contraction and relaxation of the pelvic floor muscles will be measured using ImageJ, with results expressed in millimeters (mm).
• Functional performance of Supine isometric chest lift test (Changes from baseline to 8 weeks when participants finish the intervention.)
  The Supine Isometric Chest Lift Test will be used to assess the endurance of the abdominal muscles. Participants lie in a supine position and are instructed to lift the head and shoulders off the floor, maintaining the isometric position as long as possible. The holding time is recorded in seconds
• Functional performance of Double Straight-Leg Raise Test (Changes from baseline to 8 weeks when participants finish the intervention.)
  The Double Straight-Leg Raise Test will be used to assess the endurance of the trunk flexor muscles. Participants lie supine and are instructed to raise both legs to approximately 45 degrees and maintain this position as long as possible. The holding time is recorded in seconds
• Functional performance of sorensen test (Changes from baseline to 8 weeks when participants finish the intervention.)
  The Sorensen test will be used to assess the endurance of the back extensor muscles. Participants lie prone with the upper body extended beyond the edge of a table and are instructed to maintain a horizontal trunk position as long as possible. The total holding time is recorded in seconds

Related ClearedRx care

If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.