What this trial studies
This study investigates whether ischemic preconditioning (IPC) can reduce cardiac demand after resistance exercise in older women. Aging is associated with increased cardiovascular stress, especially due to elevated blood pressure and cardiac demand during and after exercise. Strategies that can reduce this overload may improve exercise safety in older women. This is a randomized, single-blind, crossover clinical trial involving 30 women aged 60 years or older.
Conditions in scope
- Blood Pressure
- Hemodynamic Response
- Rating of Perceived Exertion
- Heart Rate
Interventions
- Ischemic Preconditioning (Device) — Ischemic preconditioning consists of three cycles of 3 minutes of arterial occlusion at a pressure 50 mmHg above systolic blood pressure, interspersed with 3 minutes of reperfusion. The procedure is applied using a blood pressure cuff positioned on the proximal…
- Sham Preconditioning (Device) — The sham condition consists of the same procedure and timing as the ischemic preconditioning protocol, using a blood pressure cuff applied to the proximal thighs in an alternating unilateral manner. However, a fixed pressure of 20 mmHg is applied, which…
Who can join
Women only · Ages 60 Years to 70 Years · Accepts healthy volunteers.
Inclusion criteria
- Female participants aged 60 years or older
- Physically independent
- Engaged in regular physical activity (at least two sessions per week for the last three months)
- Cleared for exercise participation by a cardiologist following clinical evaluation
- Able to safely perform resistance exercise
- Provided written informed consent
Exclusion criteria
- \- History of cardiovascular events such as myocardial infarction or stroke
- Uncontrolled hypertension (≥160/105 mmHg)
- Diabetes mellitus
- Current smoking or alcohol abuse
- Musculoskeletal limitations that impair exercise performance
- Cognitive or communication impairments that interfere with understanding instructions
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Uberaba | Minas Gerais | Federal University of Triângulo Mineiro (UFTM) | Unknown |
Status & timeline
- Overall status: Completed
- Study type: Interventional
- Phase: N/A
- Start date: 2025-05-28
- Primary completion: 2025-09-18
- Last update posted: 2026-03-27
- First posted: 2026-03-27
Sponsor & contact
Lead sponsor: Universidade Federal do Triangulo Mineiro (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Cardiac workload (rate-pressure product) (20 minutes post-exercise)
Cardiac workload will be assessed by the rate-pressure product (RPP), calculated as systolic blood pressure multiplied by heart rate. This measure represents an indirect index of myocardial oxygen demand and cardiac stress.
Related ClearedRx care
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Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT07497659 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.