What this trial studies
Menopause and ageing bring several changes to women's health, partly due to a decline in the hormone estrogen. This reduction affects multiple systems in the body, including muscles and bones, and also influences the production of nitric oxide, a molecule that plays a key role in regulating blood flow and blood pressure. An reduced ability to produce nitric oxide is associated with higher blood pressure and an increased risk of cardiovascular and metabolic diseases. Many women also experience lower levels of physical activity and changes in body composition during midlife, such as increased body fat and reduced muscle mass and strength, which may further decrease exercise capacity.
Conditions in scope
- Post-menopause
Interventions
- Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training (Dietary Supplement) — Intervention includes 3 sessions per week of combined strength and resistance exercise. Two of the sessions are supervised, while the third session is unsupervised-home-based.
Who can join
Women only · Ages 50 Years to 70 Years
Inclusion criteria
- Self-reported biological female and postmenopausal (≥12 months of amenorrhea)
- Aged 50-70 years
- Body mass index (BMI) 25-39.9 kg/m²
- No contraindications to exercise
- Physically inactive (\<150 minutes/week of moderate-intensity activity)
- Able to walk on a treadmill and ambulate without limitations
- Adequate proficiency in Norwegian to complete questionnaires
- Willingness and ability to comply with the study schedule and visits
Exclusion criteria
- Known allergy to nitrates or beetroot juice
- Current smoker or use of nicotine/tobacco products
- Resting blood pressure \<90/60 mmHg
- Hypertension greater than stage II (≥160/100 mmHg, ESH criteria)
- Use of prescription medications affecting heart rate (e.g., systemic β-adrenergic blockers) or nitrate availability (e.g., nitrates, proton pump inhibitors)
- History of cardiovascular disease (e.g., myocardial infarction, stroke, ischemic heart disease, peripheral artery disease, valvular disease, or aortic aneurysm)
- Symptoms suggestive of heart disease (e.g., chest pain or dyspnea)
- Major metabolic disease (e.g., type 1 or type 2 diabetes) or thyroid disorders
Eligibility wording paraphrased from the public record. View the full criteria on ClinicalTrials.gov before contacting a site.
Where it’s happening
| City | State / Region | Facility | Site status |
|---|---|---|---|
| Bergen | Western Norway University of Applied Sciences | Recruiting |
Status & timeline
- Overall status: Recruiting
- Study type: Interventional
- Phase: N/A
- Start date: 2026-02-11
- Primary completion: 2030-01-01
- Last update posted: 2026-05-07
- First posted: 2026-05-07
Sponsor & contact
Lead sponsor: Western Norway University of Applied Sciences (Other)
For trial site contact information, use the official record at ClinicalTrials.gov. Contact details change frequently and the public record is the source of truth.
Outcome measures
Primary outcomes
- Blood pressure control (Will be measured before (pre) and after (post) 12 weeks of intervention)
Blood pressure control will be assessed using two complementary outcomes: resting (absolute) blood pressure and blood pressure reactivity to standardized stressors. Together, these measures provide insight into both resting and the dynamic regulation of blood pressure in response to physiological challenges. Systolic and diastolic blood pressure will be recorded under standardized conditions using a validated automated device, with multiple readings…
Related ClearedRx care
If you’re reading this trial because you have menopause symptoms now, you don’t have to wait for a trial to access evidence-based care. ClearedRx prescribes the same FDA-approved and compounded HRT products that have been studied in trials like this one for decades.
Important. Information from ClinicalTrials.gov as of May 8, 2026. Trial details (status, sites, contacts, eligibility, outcomes) change frequently — always check the official record at https://clinicaltrials.gov/study/NCT07572877 before contacting a site.
ClearedRx is not affiliated with this trial or its sponsor. We index public-domain ClinicalTrials.gov records to help patients find evidence-based context for menopause care decisions. ClearedRx itself is a telehealth menopause/HRT brand — we do not enroll patients in trials.