Reference tool · 30 seconds · No email required

HRT Dose Equivalency Converter

Switching from a patch to a pill? Cream to a gel? Plug in your current estrogen dose and form, see roughly equivalent doses across every other delivery method.

Quick answer: The standard clinical equivalency taught at NAMS and ACOG is: 0.05 mg/day estradiol patch ≈ 1 mg oral estradiol ≈ 1.25 mg conjugated estrogens ≈ 0.5g topical estradiol gel daily ≈ 1g vaginal cream daily. Equivalents are approximate — transdermal forms bypass first-pass liver metabolism and are usually preferred for women with cardiovascular or VTE risk.

Convert from

Common doses: 0.025, 0.0375, 0.05, 0.075, 0.1 mg/day for patches; 0.5, 1, 2 mg/day for tablets; 0.625, 1.25 mg/day for CEE.

Why equivalents are approximate

Different routes hit the bloodstream differently. Transdermal estradiol (patch, gel) skips the liver on first pass — so 0.05 mg through skin per day produces about the same blood level (roughly 50 pg/mL) as 1 mg taken orally, even though the oral dose is 20x bigger by weight. Vaginal estrogen (cream, ring) is mostly local: it hits vaginal tissue strongly but barely raises systemic blood levels at standard low doses, so it does not relieve hot flashes the way patches and pills do.

This calculator gives you a rough mapping, not a prescription. Your clinician picks an actual dose based on your symptoms, history, and labs.

Embed this calculator on your site

Free to use — please keep the "Powered by ClearedRx" attribution intact.

WordPress shortcode hint: paste the iframe inside an HTML block, or use a Custom HTML widget.

Source & methodology

The equivalency table on this page reflects the standard mappings used in NAMS, ACOG, and Endocrine Society clinical guidance for menopausal hormone therapy. The base anchor is the most common one in clinical literature: 0.05 mg/day transdermal estradiol ≈ 1 mg/day oral estradiol ≈ 1.25 mg/day conjugated estrogens. Topical gel (0.5 g of 0.06% gel daily) and vaginal cream (1 g daily) are mapped at their typical "low-dose systemic" equivalents.

  • NAMS 2022 Hormone Therapy Position Statement. menopause.org
  • Endocrine Society. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2015. academic.oup.com
  • ACOG Practice Bulletin 141: Management of Menopausal Symptoms. acog.org

Related calculators

Other free menopause tools

HRT Cost Calculator

Retail vs ClearedRx flat-rate, with annual savings.

Compounded vs FDA-Approved Cost

Side-by-side cost on Estrace cream vs compounded.

FSH / Estradiol Lab Interpreter

Plug in your bloodwork, see your stage.

Menopause Rating Scale

11-item validated severity tool.

Menopause Symptom Score

Plain-English severity tool.

Perimenopause Self-Check

STRAW+10 staging.

Ready to start menopause treatment?

A board-certified MD reviews your intake within 24 hours. Flat $19–$89/month, no insurance required, free shipping nationwide.

Start Free Consultation